kirazmattson
525 posts
Sep 04, 2025
3:47 AM
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Filitra 10 mg—which contains vardenafil, a PDE5 inhibitor—and its effects on male fertility: Key Insights from Research 1. Semen Parameters and Fertility Outcomes In a randomized study of infertile men, even a single dose or alternate-day dosing (10?mg over 15 days) of vardenafil led to improvements in sperm motility, semen volume, and total sperm concentration compared to baseline PubMed . A meta-analysis covering multiple randomized controlled trials (including vardenafil) showed statistically significant improvements in: Sperm concentration Progressive motility Percentage of morphologically normal sperm PMC . 2. Long-Term Safety (6 Months of Daily Use) A well-designed, 6-month randomized, double?blind trial compared daily vardenafil (20?mg), sildenafil (100?mg), and placebo. Results showed no adverse effect of vardenafil on: Sperm concentration Total sperm count Sperm morphology or motility Reproductive hormone levels AUA Journals PubMed .Filitra 10 MG noted that even at maximum recommended doses, long?term use did not impair fertility parameters, reinforcing its safety profile Renal & Urology News . 3. Biological Mechanisms (Leydig and Sertoli Cell Function) Research suggests that vardenafil may enhance the secretory activity of Leydig and Sertoli cells, improving the biochemical environment in the testes: Increased Insulin-like factor 3 (Insl3) secretion by Leydig cells Improved androgen-binding protein expression by Sertoli cells These changes may support better sperm development and motility Wiley Online Library PMC .
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