Guest
Guest
Aug 04, 2025
9:40 AM
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Penegra 100 mg affects PDE5 enzymes because it contains Sildenafil Citrate, a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). PDE5 is found primarily in the smooth muscle cells of the penis, and it plays a role in regulating blood flow during and after sexual stimulation.
Normally, when a man is sexually aroused, the body releases nitric oxide (NO) in the penis. This activates an enzyme called guanylate cyclase, which increases levels of cyclic guanosine monophosphate (cGMP). cGMP causes the smooth muscles in the penile blood vessels to relax, allowing more blood to flow in and resulting in an erection.
PDE5 breaks down cGMP, which can end an erection. PENEGRA 100 MG works by inhibiting PDE5, allowing cGMP to remain active longer. This leads to prolonged smooth muscle relaxation, enhanced blood flow, and improved erection quality during sexual stimulation.
By specifically targeting the PDE5 enzyme, Penegra 100 mg enhances the natural erectile response without directly causing sexual arousal. However, it only works in the presence of sexual stimulation. This targeted mechanism makes Penegra effective for treating erectile dysfunction in many men. Always consult a doctor before use.
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