cliffordfosterr
Guest
Jun 19, 2025
1:49 AM
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Tadalafil—the active ingredient in Vidalista 60 mg—does not directly raise testosterone levels. Its primary action is to inhibit the PDE?5 enzyme in blood vessels, enhancing blood flow to the penis during sexual stimulation.
Here’s a deeper look:
Mechanism of action
Tadalafil enhances nitric oxide–mediated vasodilation by blocking PDE?5, increasing cGMP levels, which leads to improved erections—but it doesn’t stimulate the testes or influence the HPG axis directly.
Testosterone effects seen with some PDE?5 inhibitors
Some research—primarily with sildenafil—has observed modest increases (~100?ng/dL or ~3–3.6?nmol/L) in serum testosterone in men with ED and low baseline testosterone levels. These effects seem related to:
A possible direct testicular action since PDE?5 is present in Leydig cells.
Improved sexual function potentially influencing testosterone.
However, evidence remains limited, inconsistent, and specific to sildenafil, not tadalafil.
Lack of robust data for tadalafil
While tadalafil was included in a couple of combo studies with testosterone, these focused on erectile function outcomes rather than hormonal changes . There’s no clear clinical evidence that tadalafil independently raises testosterone.
User anecdotes are unreliable
Several anecdotal reports online (forums, Reddit) suggest generic Cialis or tadalafil might “boost testosterone,” but these are uninformed personal anecdotes and often contradictory .
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